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Oxygen Models Of Diseases

Majid Ali, M.D.

 

I proposed my Oxygen Model of Mental Health and Diseases are unifying models that explains all aspects of mental health and mental disorders—causes, clinical course, consequences, and control—on the basis of altered oxygen signaling. These abnormalities essentially begin during fetal life and continue through infancy, and childhood. This model is based on a biologist view of the brain development and neurotransmission. Autism is not a psychological or psychiatric disorder.

For instance, my Oxygen Model of Mental Health and Disorders Autism is a unifying model that explains all aspects of autism—causes, clinical course, consequences, and control—by disruptions of oxygen homeostasis occurring during fetal life, infancy, and childhood. This model is based on a biologist view of the brain development and neurotransmission. Autism is not a psychological or psychiatric disorder.

Models in science are proposed to: (1) explain such natural phenomena; (2) offer workable simplicity to reduce complexities of such phenomena; (3) predict natural phenomena hitherto unrecognized. These models are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing.

 

                  

             


 

In type 1 diabetes, insulin itself becomes a potent autoantigen and initiates autoimmune injury to pancreatic islet cells.1-3 I will show how this recently documented role of insulin in the pathogenesis of diabetes fits in the dysox model of diabetes presented here. In Type 2 diabetes, insulin cannot function – insulin resistance, in the common jargon – and hyperinsulinemia develops, which triggers and amplifies the inflammatory response.4-6 In all types of diabetes, the endothelial cells produce nitric oxide and other bioactive factors in abnormal quantities and proportions.7,8 Diabetes causes neuropathy, retinopathy, nephropathy, dementia, stroke, and heart attacks. I will describe how those complications of diabetes can be better understood when the problems are seen through the prism of oxygen signaling.

Strong clinical, epidemiologic, and experimental evidence links the epidemics of obesity with those of diabetes in an ever-increasing number of countries.9-11 That link is supported by known metabolic roles of nonesterified fatty acids (NEFAs) and altered paracrine and endocrine functions of fat cells (adipocytes) in the energy economy of the body. For example, in a healthy state, NEFAs serve as substrates for adenosine triphosphate (ATP) generation. In obesity, these fatty acids are retained in excess in biomembranes of all cell populations of the body and within adipocytes. NEFAs, along with trans fats and oxidized lipids, then "harden" the cell membranes to clamp down on insulin receptors – rusting and impacting the crank, so to speak – to cause insulin resistance.12 Those lipids also "gum up" the matrix, blocking molecular cross-talk there. Eventually, those elements, along with other toxins, uncouple respiration from oxidative phosphorylation and impede mitochondrial electron transfer events.

 

Clinical Significance of the Oxygen Model

In clinical medicine the Oxygen Model asserts that all relevant "oxygen issues" in a case—whether or not related to what appears to be the target organ of the disease process under consideration—must be effectively addressed. To cite one example, in my experience clinical results with individuals with mental issues are far superior when all relevant nutritional and environmental issues are effectively addressed. Specifically, these issues include fermentation, increased gut permeability (leaky gut state), and glucose-insulin-roller coasters.

 

Oxygen Models of Cancer

k  List of Oxygen Models of Diseases

k  Oxygen Models of Diseases

k Evidence of the Oxygen Models of Diseases

k  Evidence of the Oxygen Model of Cancer

k   The Oxygen Model of Aging

*   The Oxygen Model of Endothelial Dysfunction

k  The Oxygen Model of the Autism Spectrum

k   Premature Aging and Early Dying

k   Oxygen Model of Premature Aging

k  Aging

k   The Oxygen Models of Diseases

k   A Simple Picture Story of Oxygen Models

k   Dr. Ali's Course on Aging

k   The Oxygen Model of Aging

k  Premature Aging and Early Dying

k  Oxygen Model of Premature Aging

k The Oxygen Model of Obesity

k  The Oxyegn Model of Diabetes

k  Oxygen Model of Coronary Heart Disease

k  Oxygen Models of memory Loss and Alzheimer's Disease

 

k  Dr. Ali's Course on Aging

k  Falling Life Expectancy

k   Caloric Restriction Theory of Aging

k   Protein Cross-linking Theory of Aging

k   Fee radical Theory of Aging

k  Origin of Life, Origin of Disease

k  Oxygen-Driven Energetics: An Intelligent Design

k  Respiratory-to-Fermentative (RTF) Shift in ATP Production 

k  Fermentation: Good, Bad, and Ugly

k The Oxygen Model of Disease

k Oxygen-In-Acids-Out Healing Series

k  Oxygen's Three-Legged Throne

k  Beginning of Life

k Dysox: Energy and Detox Failure in Cells

k Molecular Biology of Oxygen Advanced

k  The dysox Model of Aging

k The Oxygen Model of Disease

k Oxygen Kaleidoscope

k  Oxygen's Three-Legged Throne

k Dysox: Energy and Detox Failure in Cells

k Molecular Biology of Oxygen Advanced

k What Does Chlorophyll Reveal About the Origin of Life on the Planet Earth?

k  Origin of Life, Origin of Disease

k  Oxygen-Driven Energetics: An Intelligent Design

k  Respiratory-to-Fermentative (RTF) Shift in ATP Production 

k Re-Thinking the Immune System

k What Does Chlorophyll Reveal About the Origin of Life on the Planet Earth?

k Dysox: Energy and Detox Failure in Cells

k Free YouTube Course on Energy Events in Health and Healing
 

k Oxidation and Oxidosis

 

k  The dysox Model of Aging

* Why Not Hydrogen for Healing?

* The Oxygen Model of Cancer - Pyruvate Kinase Evidence

* The Oxygen Model of Disease

* Dysox: Energy and Detox Failure in Cells

* Free YouTube Course on Energy Events in Health and Healing

 

 

 

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Dr. Ali discusses Dysoxygenosis and varying chronic diseases.

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