Majid Ali, M.D.
What did my microscope teach me about
leukoplakia? What do medical textbooks teach me
about leukoplakia? Most importantly, what did my
patients teach me about leukoplakia? I answer the
questions in this order and address the crucial
matter of leukoplakia turning into cancer.
What did my microscope teach
me about leukoplakia?
Leukoplakia is a chronic condition characterized by
discrete areas of thickened, roughened, and whitened
mucous membrane lining various organs. The layers of
cells multiply and are infiltrated with inflammatory
cells. With time, the cells become irregular in
outline and their nuclei become enlarged, darker,
atypical. These changes indicate a precancerous
state. If neglected and allowed to progress, such
cells become cancerous, usually after several years.
What do medical textbooks
teach me about leukoplakia?
The cause of leukoplakia is unknown. In some cases,
tobacco, either smoked or chewed, can cause
persistent irritation of mucosal lining of the oral
cavity and cause it. The term "candidal leukoplakia"
is used when leukoplakia develops in patients with
oral or systemic candidiasi. Chronic local
irritation caused by ill-fitting dentures seem to
predispose local tissues to its development. There
is no known satisfactory treatment for it except
What did my patients teach me
Leukoplakia develops as a consequence of altered
states of bowel ecology, especially the issues of
gut fermentation, excess mycotoxin production, leaky
gut state—all caused by sugar and antibiotics abuse,
undiagnosed and untreated mold allergy, food allergy
and intolerance, parasitic infestations, and
problems of indigestion and absorption. These
factors cause: (1) excess acidity in the oral cavity
and other corrosive fluids in the urinary and
genital tracts; (2) increased free radical activity
damage; (3) thickening of bodily fluids that
interfere with optimal cellular breathing; and (4)
biofilm formations over mucous linings. Biofilms are
slimy layers of tangled proteins, rancid fats, and
sticky sugars in which are embedded diverse
microbial species that protect each other from
natural and synthetic antibiotics.
The above is my explanation of the fact that most
tobacco smokers do not develop leukoplakia. So,
tobacco is a secondary factor. The same is true of
viral and bacterial populations which are present in
all oral cavities and genital and urinary tracts.
Leukoplakia is most commonly found on the insides of
the cheeks, and the surfaces of throat. Less
commonly, it involves various areas of the genital
and urinary tracts.
Cancerous Change in
In my experience, leukoplakia can be reversed with
nondrug measures that restore oral hygience and
bowel, liver, and blood ecosystems. So I advise my
patients to think holistically and act integratively
to restore the integrity of these ecosystems and not
obsess with the development of cancer. The treatment
of advanced lesions is surgical removal.
Prevention and Treatment
Since the stage for the development of leukoplakia
is set by elements in the bowel, blood, and liver,
the integrative approach requires that all relevant
factors be recognized and addressed effectively.
This allows me to make an essential point about the
integrative model: If you choose this path, it will
be the beginning of your journey of becoming your
own primary physician. You begin with clearing
leukoplakia, you will stop “rusting” in all parts of
Guidelines for Clearing
I present my guidelines for oral hygiene and for
restoring the health of the bowel and the liver in
articles on this site. I also suggest the
following:(1) Dr. Ali’s Oral Hygiene protocol; and
(2) detect and address all of the relevant factors.
I discuss these subjects at length in my two-DVD
video seminar entitled “Bowel” and a DVD video
seminar entitled “Liver” (available from
Healthy Mouth, Unhealthy Mouths
Colon Ecology - Colitis by Any Name