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The Crank-Crank-Shaft Model

of Insulin Resistance Insulin Toxicity

Majid Ali, M.D. 

I proposed The Crank-Crank-Shaft Model of Insulin Toxicity to offer a simple and visual model to explain insulin resistance, excess insulin activity (hyperinsulinemia), and insulin toxicity. In simple words, the "crank of insulin" fails to turn the "crank-shaft of insulin receptor" protein embedded in the cell membrane. This happens when the cell membrane is covered with grease—the crank-shaft is rusted, turned, and twisted, so to speak—so rendering insulin ineffective. I point out that the insulin receptor crankshaft is roughly 70 times larger than the insulin crank.

To illustrate injury to the cell membrane, I proposed The Grease and Detergent Model in which the cell innards, the cell membrane, and the cement that holds the cells together (the matrix) accumulate "cellular grease" due to insufficient detergents in the body. Cellular grease is composed of cellular waste, molecular debris, rancid fats, sticky sugars, and pulped proteins. The primary detergent in the body is oxygen, with secondary "oxy-detergents," such as hydrogen peroxide, nitric oxide, hydroxyl radicals, oxygen-activated enzymes, and grease-eating phagocytes

In cellular grease, in scientific terms, rancid fats are oxidized and peroxidized lipids, sticky sugars are glycosylated proteins and lipids, and pulped proteins are cross-linked peptides (chains of amino acids that make up proteins). This is a vast subject which I address in several articles in my Insulin Toxicity Series. Here I point out that cellular grease buildup is caused by toxic foods, toxic environment, and toxic thoughts.

In The Crank-Crank-Shaft Model of Insulin Toxicity, the blood sugar level rises when insulin fails to drive sugar into the cells to be metabolized ("burned") to produce energy. The pancreas senses the rising blood sugar levels and responds with overproduction of insulin hormone in order to overcome the resistance of cellular grease. This works for sometime. However, excess insulin is fattening, inflaming, and grease-building. So begins the vicious cycle of:

*  More grease,

*  More insulin resistance,

*  Higher blood sugar,

*  More insulin production,

*  Yet more grease,

*  Yet higher blood glucose level,

*  Yet more insulin production, and

*  Yet more grease.

In medical textbooks state that the cause of insulin resistance is unknown and the only way to lower the raised blood sugar level is to use drugs, all of which work for limited periods of time but deepen the long-term problems of excess insulin and insulin toxicity.

The cell membranes become resistant to insulin when they become chemicalizedCplasticized, so to speakCand hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively.

Clinical Significance of The Model

The crucial clinical significance of my Crank-Crank-Shaft Model is this: it compels people and their doctors to focus on the real cause of insulin toxicity, the trio of toxicities of foods, environment, and thoughts.

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* Evolution's Intelligent  Insulin Design

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