Resistance Insulin Toxicity
Majid Ali, M.D.
I proposed The Crank-Crank-Shaft
Model of Insulin Toxicity to offer a simple and
visual model to explain insulin resistance, excess
insulin activity (hyperinsulinemia), and insulin
toxicity. In simple words, the "crank of insulin"
fails to turn the "crank-shaft of insulin receptor"
protein embedded in the cell membrane. This happens
when the cell membrane is covered with grease—the
crank-shaft is rusted, turned, and twisted, so to
speak—so rendering insulin ineffective. I point out
that the insulin receptor crankshaft is roughly 70
times larger than the insulin crank.
To illustrate injury to the cell
membrane, I proposed The Grease and Detergent Model
in which the cell innards, the cell membrane, and
the cement that holds the cells together (the
matrix) accumulate "cellular grease" due to
insufficient detergents in the body. Cellular grease
is composed of cellular waste, molecular debris,
rancid fats, sticky sugars, and pulped proteins. The
primary detergent in the body is oxygen, with
secondary "oxy-detergents," such as hydrogen
peroxide, nitric oxide, hydroxyl radicals,
oxygen-activated enzymes, and grease-eating
In cellular grease, in scientific
terms, rancid fats are oxidized and peroxidized
lipids, sticky sugars are glycosylated proteins and
lipids, and pulped proteins are cross-linked
peptides (chains of amino acids that make up
proteins). This is a vast subject which I address in
several articles in my Insulin Toxicity Series. Here
I point out that cellular grease buildup is caused
by toxic foods, toxic environment, and toxic
In The Crank-Crank-Shaft Model of
Insulin Toxicity, the blood sugar level rises when
insulin fails to drive sugar into the cells to be
metabolized ("burned") to produce energy. The
pancreas senses the rising blood sugar levels and
responds with overproduction of insulin hormone in
order to overcome the resistance of cellular grease.
This works for sometime. However, excess insulin is
fattening, inflaming, and grease-building. So begins
the vicious cycle of:
More insulin resistance,
Higher blood sugar,
More insulin production,
Yet more grease,
Yet higher blood glucose level,
Yet more insulin production, and
Yet more grease.
In medical textbooks state that
the cause of insulin resistance is unknown and the
only way to lower the raised blood sugar level is to
use drugs, all of which work for limited periods of
time but deepen the long-term problems of excess
insulin and insulin toxicity.
The cell membranes become
resistant to insulin when they become chemicalizedCplasticized,
so to speakCand
hardened, immobilizing the insulin receptors
embedded in the membranes. The insulin receptor is a
protein that criss-crosses the cell membrane like a
cord. One of the consequences of grease buildup on
cell membranes is that insulin receptor becomes
turned and twisted, literally and figuratively.
Clinical Significance of The
The crucial clinical significance of my
Crank-Crank-Shaft Model is this: it compels people
and their doctors to focus on the real cause of
insulin toxicity, the trio of toxicities of foods,
environment, and thoughts.